Profhilo vs. Polynucleotides: Which Skin Treatment Is Right for You?
When it comes to non-surgical skin treatments, Profhilo and polynucleotides are two powerful options growing in popularity. Both can improve your skin’s health, but they work in slightly different ways. If you’re looking to smooth fine lines and wrinkles, restore elasticity, or give your skin a fresh, youthful glow, understanding the differences between these treatments will help you choose the right one for your needs.empowered.
What Is Profhilo?
Profhilo treatment uses pure hyaluronic acid (HA) to improve skin hydration, firmness, and texture. Unlike traditional fillers, it doesn’t add volume to the face. Instead, it spreads smoothly beneath the skin, where it works with your body to retain water molecules and boost collagen production.
Profhilo is injected into key injection sites, usually on each side of the face, and the treatment is typically spaced four to six weeks apart. Over time, it plumps the skin, improves elasticity, and leads to diminished fine lines and smoother overall tone.
What Are the Benefits of Profhilo?
• Deep hydration
• Improved skin elasticity
• Smoother texture
• More even tone
• Natural-looking results
Because it uses hyaluronic acid (HA), which occurs naturally in the body, Profhilo works well for all skin types. It helps retain water molecules, leaving your skin soft and glowing. Many clients describe the results as subtle but powerful—ideal for anyone looking to refresh their appearance without dramatic changes.
What Are Polynucleotides?
Polynucleotides, or PNs, are DNA fragments that have been shown to help with cell regeneration, collagen production, and overall skin repair. They work by targeting specific receptors in the skin to trigger healing and rejuvenation. Unlike Profhilo, which focuses mainly on hydration, polynucleotides have anti-inflammatory properties and promote tissue regeneration.
Polynucleotides are derived from salmon sperm, which is purified and adapted for cosmetic use. While that might sound surprising, it’s completely safe and scientifically proven to work. These tiny DNA chains stimulate your skin to repair itself from the inside out.
What Are the Benefits of Polynucleotides?
• Improved skin texture
• Smoother, healthier skin tone
• Reduction in acne scars and pigmentation
• Visible improvement in fine lines and wrinkles
• Support for skin muscles and joints in some advanced formulations
Polynucleotides don’t just mask imperfections—they actually treat the cause. They help your skin rebuild collagen, reduce inflammation, and heal more quickly. This makes them ideal for anyone with sensitive skin, acne scars, or signs of premature ageing.
How Do the Treatments Compare?
Profhilo and polynucleotides both offer impressive skin benefits, but they work in different ways.
Profhilo’s main ingredient is pure hyaluronic acid, which deeply hydrates the skin and improves elasticity. It helps the skin retain water molecules, leading to a glowing, plumper complexion. Typically, two sessions are required, spaced four to six weeks apart. Profhilo also plumps the skin, smooths texture, and softens fine lines and wrinkles, making it ideal for anyone seeking a fresh, radiant look.
On the other hand, polynucleotides are made from purified salmon sperm DNA. They’re known for their ability to stimulate cell regeneration, support collagen production, and promote long-term healing. Rather than simply hydrating, polynucleotides work by targeting specific receptors to rebuild damaged tissue. Most people benefit from three to four sessions. This treatment is especially effective for reducing pigmentation, repairing scars, and improving skin tone and texture. Its anti-inflammatory properties also make it suitable for sensitive or acne-prone skin.
In short, choose Profhilo if your goal is deep hydration and firmness, and consider polynucleotides if you’re looking to repair and regenerate skin from within.
Which One Should You Choose?
Both treatments are excellent, but your choice depends on your skin goals:
• Choose Profhilo if you want to deeply hydrate your skin, improve elasticity, and enjoy a natural glow. It’s ideal for those concerned about dullness, skin laxity, or early signs of ageing.
• Choose polynucleotides if you’re dealing with acne scars, sensitive skin, or need advanced rejuvenation. The treatment helps your skin repair itself and provides longer-term benefits through collagen production and improved skin texture.
Some people even combine the two treatments to get the best of both: hydration from Profhilo and regeneration from Polynucleotides.
Final Thoughts
Both Profhilo treatments and polynucleotide injections offer unique benefits, and both can help reduce fine lines and wrinkles while improving overall skin health. Whether you need deep hydration, smoother texture, or long-term repair, these treatments offer impressive, scientifically backed results.
At Renaisskin, we offer both options under the care of our qualified nurse practitioner. We’ll assess your skin’s condition and guide you towards the best treatment plan based on your personal goals.
Book Your Consultation Today
Want to find out whether Profhilo or Polynucleotides is right for you?
Book your consultation with Renaisskin today and let our expert team help you reveal smoother, firmer, and more radiant skin—naturally.
